Trends in biochemical sciences
Single-stranded DNA-binding proteins at healthy and diseased telomeres.
Gaëlle Lescalet, Alberto David Delgado Monterroso, Rima Kochman, Stéphane Coulon, Alexandre Maréchal
Published: 202610.1016/j.tibs.2025.11.010
Abstract
The repetitive G-/C-rich nature of telomeres makes them potent obstacles to replicative DNA polymerases, eliciting a state of replication stress during genome duplication. Within replisomes and as part of the shelterin complex, numerous single-strand…
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