TheriogenologyAnimalsIn Vitro Oocyte Maturation TechniquesHistone Deacetylase 6OocytesHistones
Inhibition of HDAC6 promotes in vitro maturation of Tan sheep oocytes by bidirectionally and synergistically regulating EGFR/CNP expression via histone acetylation.
Yujie Yan, Donghuan Lv, Zhipeng Qi, Xiangyan Wang, Jinghua Wang, Hongyuan Song, Junli He, Sirui Min, Qiang Chen, Xinfeng Liu
Published: 202610.1016/j.theriogenology.2025.117797
Abstract
This study aims to elucidate the regulatory role and molecular mechanism of histone deacetylase 6 (HDAC6) in the in vitro maturation (IVM) of Tan sheep oocytes. Using a granulosa cell-oocyte co-culture model supplemented with the HDAC6-specific inhib…
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