TalantaMolecular WeightMass SpectrometryAnimalsCHO CellsChromatography
Integrated native digestion and molecular weight cutoff enrichment with DIA-MS: a sensitive and selective approach for quantitative analysis of HCP.
Yachuan Gong, Yanjia Zhao, Rui Peng, Wen Qi, Yi Zhang, Ying Peng, Jiang Zheng
Published: 202610.1016/j.talanta.2025.129052
Abstract
Residual host cell proteins (HCPs) in biopharmaceutical production processes not only compromise drug efficacy but also pose risks to patient safety and product stability, particularly when high-risk HCPs are present. Continuous monitoring of HCPs co…
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