Toxicology and applied pharmacology
Paclitaxel impairs mitochondrial dynamics in human sensory-like neuron cells.
Mariana Caprio Schiess, Gessica Sabrina de Assis Silva, Natália Gabriele Hösch, Vitória Carvalho Troitiño, Marcelo Medina de Souza, Carlos DeOcesano-Pereira, Talita Glaser, Henning Ulrich, Ana Marisa Chudzinski-Tavassi, Michelle Cristiane Bufalo, Vanessa Olzon Zambelli
Published: 202610.1016/j.taap.2026.117715
Abstract
Taxanes are considered first-line chemotherapeutic agents to treat solid cancer. Paclitaxel (PTX) is a commonly used taxane and although effective, it induces peripheral chronic neuropathy in around 60-70% of patients. Studies have demonstrated a cor…
Preview only. Read the full abstract at the source