Toxicology and applied pharmacology
Pre-treatment with sevoflurane alleviates hypoxia-reoxygenation-induced cardiomyocyte damage through PAX8-AS1-targeted miR-145-5p.
Yan Xu, Xianglong Di, Ye Cai, Shilin Hu
Published: 202610.1016/j.taap.2026.117705
Abstract
OBJECTIVE: To explore the regulatory role of the lncRNA PAX8-AS1/miR-145-5p axis in the mitigation of hypoxia-induced damage to oxygenated myocardial cells by sevoflurane (Sev). METHODS: A hypoxic-reoxygenation (HR) in vitro model was established by…
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