Toxicology and applied pharmacologyAnimalsTroponin IZebrafishMyocytesCardiac
Benign cardiac troponin I release induced by elevated beat rate is associated with membrane bleb formation.
Jomana Hatahet, Hannah J Nonarath, Mark T Zafiratos, Geena Jasiek, Rebecca Kohnken, Jessica Treadway, C Michael Foley
Published: 202610.1016/j.taap.2025.117701
Abstract
Cardiac troponin I (cTnI), a key regulatory protein of cardiomyocyte contraction, serves as a clinical biomarker for cellular necrosis. Measuring circulating cTnI in preclinical studies is used to assess cardiotoxicity of new chemical entities (NCEs)…
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