Toxicology and applied pharmacologyMitophagyAnimalsPulmonary FibrosisHumansA549 Cells
Shionone ameliorates pulmonary fibrosis by activating mitophagy via PINK1-Parkin pathway.
Yijia Su, Qiang Fu, Xilin Wu, Xianhua Che, Zhe Jiang, Xuezheng Li
Published: 202610.1016/j.taap.2025.117693
Abstract
Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited clinical treatment options. Shionone (SHI), a major active compound derived from Ligularia fischeri Turcz (LF), has shown pharmacological potential; however, it…
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