Toxicology and applied pharmacologyPentacyclic TriterpenesCarcinomaHepatocellularAnimalsHumans
Celastrol delays the progression of hepatocellular carcinoma by suppressing SLC1A5-mediated glutamine dependence.
Simeng Xiao, Yun Zhao, Zhiguo Chen, Yangkun Xiong, Dingmei Zhang, Gang Zhou, Cong Zhang
Published: 202610.1016/j.taap.2025.117690
Abstract
Hepatocellular carcinoma (HCC) is a serious public health problem worldwide due to its high mortality rate and specific therapeutic strategies with rare effective drugs. Glutamine, a critical nutrient for sustaining the cellular vital activities, has…
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