Toxicology and applied pharmacologyNF-E2-Related Factor 2Hep G2 CellsHumansAuranofinReactive Oxygen Species
Aurocyanide, an active metabolite of auranofin, exerts cytoprotective effects via ROS-mediated Nrf2 activation in HepG2 cells.
Undarmaa Otgontenger, Seokwon Yang, Eun Kyung Kim, Young-Mi Kim
Published: 202610.1016/j.taap.2025.117656
Abstract
Auranofin, an FDA-approved oral gold(I) compound for rheumatoid arthritis, is being repurposed due to its established clinical safety and emerging therapeutic potential. Given its extensive in vivo metabolism, identifying active metabolites and chara…
Preview only. Read the full abstract at the source