Toxicology and applied pharmacologyAnimalsLignansCyclooctanesChemical and Drug Induced Liver InjuryMale
Schisantherin A alleviates hepatotoxicity induced by diosbulbin B in mice via suppressing metabolic activation of diosbulbin B.
Shuo Wang, Bufan Yang, Guangyao Li, Dongju Lin
Published: 202610.1016/j.taap.2025.117644
Abstract
Diosbulbin B (DLB) is the most abundant diterpene lactone in herbal medicine Dioscorea bulbifera L. (DB). DLB is able to cause severe liver injury. The early studies showed that CYP3A4-mediated metabolic activation of DLB to form the corresponding ci…
Preview only. Read the full abstract at the source