Toxicology and applied pharmacologyLignansHepatic Stellate CellsAnimalsLysosomesBiphenyl Compounds
Honokiol ameliorates hepatic fibrosis by inducing lysosomal membrane permeabilization and impairing lipophagy in hepatic stellate cells.
Zhiyi Wang, Zibo Li, Wenlong Yang, Yuyue Li, Ziyang Huang, Zhenzhen Guo, Erping Xu, Ming Bai, Yucheng Li
Published: 202610.1016/j.taap.2025.117632
Abstract
Lipophagy in HSCs (hepatic stellate cells) is associated with loss of stellate cell retinol storage and increased β oxidation rate, indicating that the increase in lipophagy serves to provide energy for HSC activation, and contributes to hepatic fibr…
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