Toxicology and applied pharmacology
Hederagenin exerts anti-tumor effects in pancreatic cancer by impairing DRP1 mediated-mitophagy via VDAC1-HK2-PINK1/PARKIN pathway.
Fang Su, Jianhua Yu, Shenhao Xu, Huanjun Tong, Jiandong Li, Fangfang Tao, Baochun Lu
Published: 202510.1016/j.taap.2025.117586
Abstract
Pancreatic cancer (PC) is widely regarded as the deadliest form of malignancy with a notably bleak prognosis. Although survival rates have shown gradual improvements, the pace of advancement remains slower when compared to other forms of cancer. Mito…
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