Structure (London, England : 1993)HumansVesicular Acetylcholine Transport ProteinsCryoelectron MicroscopyProtein BindingBinding Sites
Decoding VAChT inhibition: Structural insights into cholinergic transporter modulation.
Xiaobo Chen, Jing Xue
Published: 202610.1016/j.str.2025.12.006
Abstract
In this issue of Structure, Zhang et al.1 present two cryoelectron microscopy (cryo-EM) structures of the human vesicular acetylcholine transporter bound to the inhibitors spiroindoline and alkylsulfone. The conserved center paired with flexible subp…
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