Structure (London, England : 1993)
The impact of N-glycan conformational entropy on the binding affinity of Fc γ receptor IIIa/CD16a.
Paul G Kremer, William D Tolbert, Eliza Gazaway, Braulio G Hernandez, Marek K Korzeniowski, Zofia A Dyba, Tobias Grelsson, Oliver C Grant, William N Lanzilotta, Marzena Pazgier, Robert J Woods, Adam W Barb
Published: 202510.1016/j.str.2025.11.015
Abstract
The affinity of Fc γ receptor IIIa (FcγRIIIa) binding to immunoglobulin G1 (IgG1) correlates with patient responses for antibody-based therapeutics. Among multiple factors affecting affinity, a mechanism defining how the composition of the FcγRIIIa N…
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