Structure (London, England : 1993)
γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation.
Riki Maruyama, Akio Fukumori, Satoru Funamoto, Ken Okada, Shoshin Akamine, Kanta Yanagida, Mitsuru Shinohara, Naoyuki Sato, Masayasu Okochi, Takashi Kudo, Harald Steiner
Published: 202510.1016/j.str.2025.11.010
Abstract
Intramembrane proteolysis by γ-secretase is critically implicated in Alzheimer disease pathogenesis by processing of its amyloid precursor protein substrate C99 into harmful amyloid-β peptide (Aβ) species. Recruitment of C99 involves binding of its N…
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