Structure (London, England : 1993)Vibrio choleraePerforinModelsMolecularProtein Binding
Cradle loop regulates β-barrel pore-formation mechanism of Vibrio cholerae cytolysin.
Mahendra Singh, Arnab Chatterjee, Ananya Nayak, Prasenjit Naskar, Gurvinder Kaur, Jagannath Mondal, Somnath Dutta, Kausik Chattopadhyay
Published: 202610.1016/j.str.2025.10.013
Abstract
Vibrio cholerae cytolysin (VCC) is a β-barrel pore-forming toxin (β-PFT). The membrane insertion of its pore-forming "pre-stem" motif is the most crucial step in the pore-formation mechanism. In the soluble monomeric form, pre-stem remains clamped ag…
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