Steroids5'-NucleotidaseHumansPentacyclic TriterpenesEnzyme InhibitorsAnimals
Discovery of dihydrobetulinic acid as a potent small molecule CD73 inhibitor.
Hongling Wang, Yanming Zhang, Chunyang Lou, Xuliang Chang, Hang Yang, Daozuan Zhang, Haijun Ma, Zhenyuan Miao
Published: 202610.1016/j.steroids.2025.109719
Abstract
Betulinic acid (BA) is a pentacyclic triterpene compound with various biological activities. Herein, we designed and synthesized a series of dihydrobetulinic acid (DHBA) and its derivatives for the discovery of potent ecto-5'-nucleotidase (CD73) inhi…
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