Stem cell reportsHumansAnimalsInduced Pluripotent Stem CellsNeuronsMice
Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts.
Jacqueline Fréderique Maria van Vierbergen, Carles Calatayud, Sriram Balusu, Nicolò Carrano, Nicolas Peredo, Katlijn Vints, Sandra Fernández Gallego, Katrien Horré, Bart De Strooper, Patrik Verstreken
Published: 202610.1016/j.stemcr.2025.102754
Abstract
Xenotransplantation enables the interrogation of human neuron-specific vulnerabilities to Alzheimer's pathology within a physiologically relevant in vivo context. While amyloid-beta (Aβ) is known to disrupt synaptic integrity, it remains uncertain wh…
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