Stem cell reportsLeukemiaMyelogenousChronicBCR-ABL PositiveMitophagy
Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells.
Ting Song, Yang Song, Hong Zhang, Zhiyuan Hu, Fangkui Yin, Maojun Jiang, Yanxin Zhang, Ziqian Wang, Zhichao Zhang
Published: 202610.1016/j.stemcr.2025.102751
Abstract
In chronic myeloid leukemia (CML), disease persistence in patients is maintained by leukemic stem cells (LSCs), which drive tyrosine kinase inhibitor (TKI) resistance. Autophagy has been proposed as a potential therapy to eradicate CML LSCs. Here, us…
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