Stem cell reportsAnimalsMitochondriaPyruvic AcidHumansAsthma
Mitochondrial pyruvate metabolism in club cells drives airway inflammation.
Jianhai Wang, Chunnan Du, De Hao, Qian Wu, Biyu Gui, Yu Li, Kuan Li, Xue Li, Qiuyang Zhang, Li Li, Huaiyong Chen
Published: 202610.1016/j.stemcr.2025.102742
Abstract
Asthma is a chronic inflammatory airway disease characterized by defective epithelial repair, resulting from metabolic dysregulation in facultative progenitor cells. Here, we investigate how pyruvate metabolism in airway club cells controls epithelia…
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