Cell stem cellHumansOrganoidsGangliaSympatheticPluripotent Stem Cells
Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart.
Yantong Liu, Jinkui Zhu, Xiaoxiang Lu, Xuran Zhuang, Jianfeng Wei, Linlin Jiang, Wei Zhou, Wei Pang, Yao Yin, Ziling Chen, Yajing Cao, Qinzhi Zhang, Sisi Chen, Siyuan Chu, Xinrui Zhang
Published: 202610.1016/j.stem.2025.11.003
Abstract
The sympathetic ganglia are essential components of the nervous system that regulate various aspects of involuntary body functions. Recapitulating sympathetic ganglion development with three-dimensional (3D) organoids is challenging and has not been…
Preview only. Read the full abstract at the source