Cell stem cellAnimalsClusterinMyocytesCardiacRegeneration
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages.
Lei Fan, Qi Tang, Yutong Wang, Hang Sun, Ge Li, Yi Yang, Huiying Zhu, Zhaoyuan Liu, He Wang, Hongyan Wang, Qing Jing, Christopher L Antos, Hui Xiao, Renchu Guan, Gang Pei
Published: 202510.1016/j.stem.2025.10.008
Abstract
Adult hearts scar after injury, while neonatal hearts regenerate. The mechanisms underlying this dichotomy remain unclear. Through comparative spatiotemporal single-cell analyses and dual recombinase-mediated lineage tracing, we uncovered an injury-i…
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