Cell stem cellAnimalsLung NeoplasmsCyclin-Dependent Kinase Inhibitor p16HumansMice
Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity.
Jin Young Lee, Nabora Reyes, Sang-Ho Woo, Nancy C Allen, Tsukasa Kadota, Andrew Lechner, Ritusree Biswas, Sakshi Goel, Fia Stratton, Chaoyuan Kuang, Tatsuya Tsukui, Vincent Auyeung, Aaron S Mansfield, Lindsay M LaFave, Tien Peng
Published: 202510.1016/j.stem.2025.10.005
Abstract
Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identify p16Ink4a+ cancer-associated f…
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