Cell stem cellHumansOrganoidsBasal Nucleus of MeynertAnimalsCholinergic Neurons
Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids.
Da Wang, Xinyue Zhang, Xiao-Yan Tang, Yixia Gan, Hanwen Yu, Shanshan Wu, Yuan Hong, Mengdan Tao, Chu Chu, Xiaoxuan Qi, Hao Hu, Yimin Zhu, Wanying Zhu, Xiao Han, Min Xu
Published: 202510.1016/j.stem.2025.10.004
Abstract
The nucleus basalis of Meynert (nbM), the major cholinergic output of the basal forebrain, regulates cortical modulation, learning, and memory. Dysfunction of the nbM-cortical cholinergic pathway is implicated in neurodegenerative and neurodevelopmen…
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