Seminars in immunologyHumansOncolytic VirotherapyOncolytic VirusesReoviridaeNeoplasms
Reovirus oncolysis and the next frontiers for this unique oncoviral immunotherapy.
Negar Sharifi, Amir Emamie, Nastaran Rafiee, Salar Pashangzadeh, Eknoor Walia, Nikolas Tim Martin, Huy-Dung Hoang, Xiao Xiang, Tommy Alain
Published: 202510.1016/j.smim.2025.101995
Abstract
Reovirus is one of the most clinically investigated oncolytic viruses, with over 50 clinical trials and more than 1700 patients treated to date. Although it has yet to achieve complete regulatory approval, reovirus remains a promising oncolytic virus…
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