Sleep medicineHumansMajor Depressive DisorderMaleHypothalamo-Hypophyseal SystemFemale
Clock gene influences on sleep quality and HPA axis in major depressive disorder.
Alex Ferrer, Ariadna Pelegrí, Javier Labad, Teresa Sagués, Neus Salvat-Pujol, Aida de Arriba-Arnau, José M Menchón, Diego Palao, Javier Costas, Angel Carracedo, Virginia Soria
Published: 202610.1016/j.sleep.2025.108730
Abstract
BACKGROUND: Major Depressive Disorder (MDD) has been associated with disruptions in circadian rhythms and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Circadian rhythms are regulated by "clock" genes, including BMAL1, which are als…
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