SLAS discovery : advancing life sciences R & DHumansDrug DiscoveryReceptorsCytokineCytokines
From Large to Small Cytokine Receptor Antagonists.
Pawel Leznicki, Karl Deacon, Bohdan Waszkowycz, John F Unitt
Published: 202610.1016/j.slasd.2025.100280
Abstract
Here, we review general trends in biological and small molecule cytokine drug discovery, highlighting key learnings from two successful case studies (TNFα and IL-17), which have helped shape our understanding of how best to identify new small molecul…
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