Seminars in oncologyHumansGene EditingNeoplasmsProgrammed Cell Death 1 ReceptorAnimals
Genome editing of immune checkpoints: CRISPR-mediated PD-1 inhibition in cancer.
Suleiman Ibrahim Mohammad, A K Kareem, Asokan Vasudevan, M M Rekha, Majid S Jabir, PriyaPriyadarshini Nayak, Zahraa AlKhafaje, Vimal Arora, WesamR Kadhum, Kattela Chennakesavulu
Published: 202610.1016/j.seminoncol.2025.152438
Abstract
The programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint is a primary mechanism by which tumors evade immune surveillance, limiting the efficacy of cytotoxic T lymphocytes (CTLs) and tumor-infiltrating lymphocyte…
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