Seminars in cancer biology
Lipid dysregulation in renal cancer: Drivers of tumor growth and determinants of treatment-induced toxicity.
Mohammed Alnukhali, Alessia Fornoni, Alan Pollack, Anis Ahmad
Published: 202610.1016/j.semcancer.2025.12.010
Abstract
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) exhibits a distinctive metabolic signature marked by the excessive buildup of cholesterol and neutral lipids. This phenotype stems largely from the loss of the von Hippel-Lindau (VHL) tumor suppress…
Preview only. Read the full abstract at the source