Stem cell researchHumansInduced Pluripotent Stem CellsCRISPR-Cas SystemsGene EditingPerilipin-2
Generation of a PLIN2-GFP2-P2A-Puro human induced pluripotent stem cell line (SEUi001-A) via CRISPR/Cas9-mediated gene editing technology.
Meng Fan, Meiyan Zhao, Wenjun Su, Zhantong Tang, Wenheng Sun, Tao Zhou, Pengyu Liu
Published: 202610.1016/j.scr.2025.103896
Abstract
Perilipin 2 (PLIN2) dysregulation drives metabolic pathologies including non-alcoholic fatty liver disease (NAFLD). To enable real-time tracking of PLIN2 dynamics, we established a human induced pluripotent stem cell (hiPSC) line with endogenous GFP2…
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