Stem cell researchHumansHuman Embryonic Stem CellsPhosphotransferases (Alcohol Group Acceptor)Cell LineCRISPR-Cas Systems
Generation of a pluripotent human AGK knockout embryonic stem cell model (WAe009-A-3C) of Sengers syndrome.
Yau Chung Low, Cameron L McKnight, Diana Stojanovski, David R Thorburn, Ann E Frazier
Published: 202610.1016/j.scr.2025.103895
Abstract
Sengers syndrome is a rare mitochondrial disorder caused by the loss of a nuclear encoded mitochondrial protein, acylglycerol kinase (AGK). Here, we describe the generation of a novel in vitro stem cell model of Sengers syndrome (AGKKO C10) using CRI…
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