Science bulletinHumansEndoplasmic Reticulum StressApoptosisHistone DemethylasesAnimals
LD-110, a potent LSD1 PROTAC degrader, suppresses tumor growth by inducing ER stress and apoptosis.
Danyi Zhai, Jiezhen Zhuo, Yudong Yin, Lan Li, Mengting Liang, Xin Zhou, Lihua Liu, Liangzhen Chen, Xiufang Xiong, Qing Yu, Xin Han, Yi Sun
Published: 202510.1016/j.scib.2025.10.024
Abstract
Lysine-specific demethylase 1 (LSD1, also known as KDM1A) is frequently overexpressed in multiple cancer types and associated with poor prognosis of cancer patients. While LSD1 represents a compelling therapeutic target, clinical development of small…
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