Science bulletinReceptorsG-Protein-CoupledSignal TransductionCholesterolHumans
Structural insight into GPR155-mediated cholesterol sensing and signal transduction.
Delin Li, Xiaokang Zhang, Jie Feng, Yufeng Xie, Pu Han, Ming He, Lin Hao, Tianling Guo, Xiaoyi Bai, Kai Yuan, Junqing Sun, Xuefei Pang, Yan Wu, Yingxia Liu, George Fu Gao
Published: 202510.1016/j.scib.2025.09.012
Abstract
Cholesterol (CHL) serves as a building block for membrane biogenesis and a precursor to oxysterols, steroid hormones, bile acids, and vitamin D. The lysosome serves as a major sorting station for low-density lipoproteins (LDLs), which carry dietary C…
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