Schizophrenia researchHumansMaleFemalePsychotic DisordersAdult
Complement C4 gene copy numbers modulate serum immune protein profiles in patients with first-episode psychosis and healthy controls in a sex-specific manner.
Uni Rankka, Marja-Liisa Lokki, Vesa Vahermaa, Heikki Laurikainen, Jarmo Hietala, Jarno Honkanen, Seppo Meri, Jaana Suvisaari
Published: 202510.1016/j.schres.2025.10.001
Abstract
BACKGROUND: The copy number of complement component C4 genes (C4A and C4B) has been associated with schizophrenia risk, particularly in men. Psychotic disorders are associated with alterations in serum immune protein levels, but whether the C4A/B cop…
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