Current opinion in structural biology
The current understanding of KRAS oligomerization on membranes.
Nastazia Lesgidou, Michail Papadourakis, Nishita Mandal, Sepehr Dehghani-Ghahnaviyeh, Camilo Velez-Vega, José S Duca, Zoe Cournia
Published: 202510.1016/j.sbi.2025.103190
Abstract
KRAS, a member of the RAS family of small GTPases, is frequently mutated in cancers and localizes to the inner leaflet of the plasma membrane, where it has been suggested to form dimers and higher-order oligomers (nanoclusters). These nanoclusters ar…
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