Recent breakthroughs in understanding the allosteric features of Ras GTPases and their effector and regulatory protein interactions, enabling drug design.

Ras guaosine triphosphate hydrolase (GTPase) are central to key cell signaling pathways and, when mutated, drive many cancers. Thought to be undruggable, dramatic progress has been made in the last decade in the design and screening of drugs, in larg…

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