Reproductive toxicology (Elmsford, N.Y.)HumansFemaleOvaryAdrenal GlandsEndocrine Disruptors
Comparison of steroidogenic disruption in adrenal H295R and ovarian KGN and COV434 cell models and the implications to assess female reproductive toxicity.
Paraskevi Vazakidou, Charlotte Koopmans, Sandra Nijmeijer, Laetitia L Lecante, Peng Liu, Séverine Mazaud-Guittot, Paul A Fowler, Pim E G Leonards, Majorie B M van Duursen
Published: 202610.1016/j.reprotox.2025.109088
Abstract
To investigate the need for an ovarian-specific steroidogenesis assay in regulatory testing, steroid hormone profiles from adrenal H295R and ovarian KGN and COV434 cell cultures were compared with primary human cultures using LC-MS/MS. Hierarchical c…
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