Reproductive toxicology (Elmsford, N.Y.)FemaleHumansPrimary Ovarian InsufficiencyMolecular Docking SimulationFluorocarbons
Network toxicology and molecular simulation identify key genes and pathways in PFAS-induced premature ovarian insufficiency.
Jiyu Che, Yanyan Qu, Weiran Liu, Yong Zhang, Zhongming Wu
Published: 202510.1016/j.reprotox.2025.109086
Abstract
Premature ovarian insufficiency (POI) is a reproductive disorder characterized by the early loss of ovarian function in women under 40 years of age. PFAS, especially PFOA and PFOS, have been implicated in ovarian dysfunction, but their mechanisms of…
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