Reproductive toxicology (Elmsford, N.Y.)MaleAnimalsTestisKelch-Like ECH-Associated Protein 1Mice
Irreversible male infertility from sleep restriction: A dual hit on testicular steroidogenesis and Keap1-Nrf2-mediated antioxidant defense.
Keke Chen, Fengyou Luo, Xiling Huang, Kaixing Huang, Xiaoyu Liu, Qiping Hu, Changlong Xu
Published: 202510.1016/j.reprotox.2025.109083
Abstract
BACKGROUND: Chronic sleep restriction (SR) threatens male reproductive health, yet the mechanisms underlying the partial reversibility of the induced damage remain unclear. We hypothesized that this persistent infertility stems from a "dual-hit" mech…
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