Redox biology
p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.
Jing Tong, Tao Han, Jun Deng, Yu Gan, Ruiwen Ruan, Wei Zhao, Chen Xiong, Quan Liao, Shiqi Chen, Huitong Bu, Jianping Xiong, Xiang Zhou, Qian Hao
Published: 202610.1016/j.redox.2026.104043
Abstract
In colorectal cancer (CRC), p53 can either suppress or potentiate tumor sensitivity to ferroptosis under oxidative stress conditions. However, it remains to be elucidated how p53 differentially regulates ferroptosis, and whether it can initiate ferro…
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