Redox biology
Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOS.
Zhengquan Zhu, Yihan Wang, Xinye Yu, Tingyu Wang, Yin Li, Ruizhe Wang, Haiyun Chen, Binjia Ruan, Wangsen Cao, Gaojian Tao, Yong Wang, Daojuan Wang
Published: 202610.1016/j.redox.2026.104034
Abstract
Arrested follicular development and anovulation are hallmarks of polycystic ovary syndrome (PCOS), in which granulosa cell (GC) ferroptosis is emerging as a potential contributor. However, its precise role and regulation remain largely unknown. Here,…
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