Redox biology
Mitochondrial acetyl-CoA reprogramming by the SIRT3-ACSS2-OPA1 axis confers resistance to ferroptosis in Parkinson's disease.
Xv-Shen Ding, Bao Wang, Zheng Han, Chen-Xi Feng, Yang-Ni Li, Yu-Fei Wang, Jian-Cai Guru, Jie Cao, Rui-Li Zhang, Xue-Lian Wang, Qian Yang, Yan Qu, Li Gao
Published: 202610.1016/j.redox.2026.104030
Abstract
Mitochondrial dysfunction and ferroptosis have emerged as pivotal contributors to dopaminergic (DA) neuron degeneration in Parkinson's disease (PD). Here, a previously unrecognized SIRT3-ACSS2-OPA1 axis that couples mitochondrial acetyl-CoA (Ac-CoA)…
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