Reproductive biomedicine online
Oocyte-mediated repair of sperm DNA fragmentation: a critical determinant of embryo viability.
Maria Luisa Pardiñas, Carlos de Celis, Julia Gil, David Ortega-Jaen, Angel Martin, Amparo Mercader, Maria Jose de Los Santos
Published: 202510.1016/j.rbmo.2025.105165
Abstract
DNA repair capacity is a critical biological process for maintaining genomic integrity in cells. However, certain cells, such as spermatozoa, possess limited DNA repair ability and depend on the oocyte for this function during fertilization. Among th…
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