Progress in neuro-psychopharmacology & biological psychiatryHumansClozapineMaleFemaleAdult
Population pharmacokinetic analysis for simultaneous fit of clozapine and norclozapine concentrations in adult psychiatric patients.
Bojana Panić, Vera Lukić, Katarina Vučićević, Branislava Miljković, Srđan Milovanović, Marija Jovanović
Published: 202610.1016/j.pnpbp.2025.111583
Abstract
BACKGROUND: Clozapine (CLZ) exhibits a high potential for pharmacokinetic interactions due to its extensive and complex metabolism. Additionally, several patient-related factors contribute to the pharmacokinetic variability, making treatment optimiza…
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