Progress in neuro-psychopharmacology & biological psychiatryReceptorsDopamine D2HumansCyclic AMPbeta-Arrestins
Distinct functional profiles of partial agonist antipsychotics in cAMP and β-arrestin signaling mechanisms of dopamine D2 and D3 receptors in vitro.
Katalin Domány-Kovács, Sándor Kolok, Dalma Kurkó, Zsófia Bekes, Ferenc Horti, Amrita Bobok, József Nagy, Zoltán Kapui, Balázs Lendvai, András Visegrády, Béla Kiss
Published: 202510.1016/j.pnpbp.2025.111554
Abstract
Aripiprazole, brexpiprazole and cariprazine represent a new generation of atypical antipsychotics with partial agonist activity at dopamine D2 and D3 receptors. So far, the functional activity of these partial agonists has mainly been studied at G-pr…
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