Progress in neuro-psychopharmacology & biological psychiatryAlzheimer DiseaseAluminum ChlorideAnimalsProto-Oncogene Proteins c-aktHumans
Agnuside enhances neuronal survival and cognitive function by modulating PI3K/AKT/mTOR signaling in Aluminium Chloride induced Alzheimer's disease.
Roselin Gnanarajan, Deenathayalan Uvarajan, Nandita Ravichandran, Panimalar Abirami Karuppusamy, Kavithaa Krishnamoorthy, Balachandar Vellingiri, Arul Narayanasamy
Published: 202510.1016/j.pnpbp.2025.111532
Abstract
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by chronic inflammation, oxidative stress, and amyloid beta (Aβ) aggregation. Prolonged exposure to heavy metals such as aluminium (Al) promotes reactive oxygen spe…
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