Progress in neuro-psychopharmacology & biological psychiatryHumansDepressive DisorderTreatment-ResistantInduced Pluripotent Stem CellsGABAergic Neurons
Dysregulation of glutamatergic and GABAergic neurons in Treatment-Resistant Depression: Insights from patient-derived neurons.
Zaira Tomasoni, Federica Bono, Giulia Sbrini, Adele Guglielmi, Veronica Mutti, Jessica Mingardi, Laura Musazzi, Alice Filippini, Sergio Ferraboli, Cristina Missale, Marco Bortolomasi, Alessandra Minelli, Massimo Gennarelli, Alessandro Barbon, Chiara Fiorentini
Published: 202510.1016/j.pnpbp.2025.111527
Abstract
Major depressive disorder (MDD) is a common condition and a leading cause of global health burden. Despite the availability of pharmacological treatments, many patients do not respond to at least two antidepressant therapies, leading to treatment-res…
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