Progress in neuro-psychopharmacology & biological psychiatryAnimalsMalePsilocybinMiceInbred C57BL
Differential effects of psilocybin and lisuride on serotonin and dopamine neuronal activity and behavior.
Brandon Richardson, Antonio Inserra, Michael Pileggi, Thomas Prud'Homme, Vitor Bruno, Derek Wan-Yan-Chan, Ilia Shareghi-Ghahreman, Sofia Nasini, Tadhg Strand, Marco Leyton, Nahum Sonenberg, Danilo De Gregorio, Jeffrey Sprouse, Francis R Bambico, Gabriella Gobbi
Published: 202510.1016/j.pnpbp.2025.111522
Abstract
Psilocybin and lisuride are 5-HT2A receptor agonists, but only psilocybin elicits the head twitch response (HTR) in rodents, a behavior commonly used as a proxy for hallucinogenic activity. This study aimed to compare their effects on serotonin (5-HT…
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