Placenta
Elucidating the role of ABC transporters in the placental efflux of (-)- Δ9-tetrahydrocannabinol (THC) using a cocktail of ABC transport inhibitors.
Ankit Balhara, Xin Chen, Aditya R Kumar, Morgan E Wasickanin, Joshua W Monson, Jennifer R Damicis, Hillary J Kinsman, Nicholas Ieronimakis, Jashvant D Unadkat
Published: 202510.1016/j.placenta.2025.12.012
Abstract
We previously showed that THC is effluxed in the perfused human placenta cotyledons, but surprisingly this efflux was not inhibited by valspodar, a P-gp and BCRP inhibitor. P-gp and BCRP have multiple binding sites, and therefore THC may be binding t…
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