PlacentaAnimalsFemaleMetforminPregnancyDiet
Metformin mitigates placental dysfunction by modulating gene expressions in a high-fat diet-induced rat model.
Yu-Ju Lin, Yin-Hua Cheng, Ni-Chin Tsai, Li-Tung Huang, Hong-Ren Yu, You-Lin Tain, I-Chun Lin, Kuo-Chung Lan
Published: 202510.1016/j.placenta.2025.10.020
Abstract
BACKGROUND: Maternal obesity impairs placental development and function, contributing to adverse fetal outcomes through disrupted gene regulation and metabolic homeostasis. Metformin, an insulin-sensitizing agent, may mitigate these effects by modula…
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